Seizures in neonates are usually caused by hypoxia and can increase risk of later epilepsy and cognitive impairment. Rakhade et al. induced hypoxic seizures in early postnatal rats to identify molecular changes that increase seizure susceptibility. Seizures increased the amplitude and frequency of miniature and spontaneous EPSCs mediated by AMPA receptors (AMPARs) within 1 h.

It's a Catch-22 of the highest order. People with alcohol problems often use alcohol to get to sleep -- but it actually keeps them from getting good-quality sleep all night long. At the same time, they're highly likely to suffer from full-blown chronic insomnia that keeps them from getting enough sleep night after night - and that condition has been shown to cut their chances of getting sober again.

UCB announced that it received a not-approvable letter from the U.S. Food and Drug Administration (FDA) for lacosamide for the treatment of diabetic neuropathic pain in adults. The company will seek clarification from the FDA of its position and of the additional information required to obtain final marketing approval.

Debra Satterfield sat in yet another hospital room awaiting a diagnosis for the disorder that caused her eight-year-old son to suffer as many as 400 seizures a day. As she waited, Satterfield jotted down notes about her surroundings and experiences. Three years later her son's severe epilepsy under control the design researcher is teaming up with the Mayo Clinic to transform those personal observations into a more satisfying health care experience for others.

Pregnant women with epilepsy who took the seizure drug topiramate, which is sold by Johnson and Johnson under the brand name Topamax, increased their risk of having an infant with birth defects, especially when taken in combination with another drug called valproate, according to a study published in the July 22 issue of journal Neurology, the